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Guidance for the in-house preparation of quality control materials (QCMs) Ingestion-build-54484 An environmental manager’s guide to1 Scope This Guide outlines the essential characteristics of reference materials for quality control (QC) purposes, and describes the processes by which they can be prepared by competent staff within the facility in which they will be used (i. e. where instability due to transportation conditions is avoided). The content of this Guide also applies to inherently stable materials, which can be transported to other locations without risk of any